Lenalidomide - Lenangio 10mg tablet online | Myapplepharma

Lenangio 10mg is belongs to anticancer medication which contains Lenalidomide as an active substance which belongs to thalidomide analogue.
Lenangio 10mg is used to the disease condition by combining with dexamethasone.
Lenangio 10mg consist of some other pharmacological activities like immuno modulatory & anti-angiogenesis.
Lenangio 10mg is a prescription drug that can only use under the supervision of medical oncologist.

INDICATION

The indications of Lenangio 10mg are;
Lenangio combination with dexamethasone is indicated to treat the patients suffered from multiple myeloma
Lenangio is indicated for the patients having transfusion-dependent anemia because of intermediate 1 risk myelodysplastic syndrome along with deletion 5q cytogenetic abnormality without or without addition cytogenetic abnormalities
Lenangio is used to treat the patients with mantle cell lymphoma in which its used whose the disease was relapsed or progressed after two before treatment, especially the disease not response with the bortezomib therapy.

The adult usual dose of Lenangio 10mg in myelodysplastic syndromes is 10mg and administrated once a day.
For renal damaged patients;
CrCl >60ml/min In Patients should not needed dosage adjustment of Lenangio
CrCl 30 to 60ml/min In Patients, 5mg of Lenangio should administer orally as once daily
CrCl <30ml/min In Patient, 2.5mg of Lenangio should be given orally as a once daily.
Dosage variation;

Thrombocytopenia:

Drops to <50000/mcL, treatment should be interrupted. Back to > or equal to 50000/mcL, follow the Lenangio of 5mg per day.
Neutropenia;
Drops to <500/mcL, treatment should be delayed. Back to > or equal to 500/mcL, treatment should be follow to 5mg per day.
Multiple myeloma;
In this disease, concomitant use of dexamethasone with Lenangio. The regular dose of Lenangio is 25mg should be given as once in a day on day 1 to 21.
The dose of dexamethasone;
Dexamethasone 40mg should be continued on day 1 to 4, 9 to 12 & 17 to 20 of each period of 28-day cycles. Patient with greater than 75 years, dexamethasone 20mg should be prescribed on day 1, 8, 15, & 22.
Mantle cell lymphoma;
The usual dose of Lenangio for this disease is 25mg should be given orally as once daily.
For renal damaged patients;
CrCl 30 to 60ml/min in patient, Lenangio 10mg should be given as once daily. CrCl <30ml/min in patients, Lenangio 15mg should be used for q48hr.
Pediatrics;
The safety & efficiency of Lenalidomide has not been described in pediatric patients with age of <18 years.

MECHANISM

Lenangio 10mg involves in the prudence of tumor and factor alpha arrangement, that reinforcement the T-cells and leads to lessening plasma levels of cytokines vascular endothelial growth factor and fundamental fibroblast growth factor.
Lenangio 10mg is moreover engaged with the stave off angiogenesis.
Lenalidomide is furthermore authorize G1 cell cycle capture and apoptosis of ruinous cells.

PHARMACOKINETICS

Absorption:

Absorbed rapidly with peak plasma concentration is between 0.625 and 1.5 hrs. combining with food will not change the prolong of absorption but dose decrease in Cmax.

Distribution:

Bounding of plasma protein is 30%

Metabolism:

Mainly metabolized in two metabolites is hydroxy-lenalidomide and N-acetyl-lenalidomide.

Excretion:

Primarily eliminated in renal route and the dose excreted via urine 90% and feces 4% and half-life is 3hrs.

DRUG INTERACTION

Interaction of Lenangio 10mg with digoxin leads to increased concentration of digoxin causes increased risk of adverse effects related to digoxin.
Interaction of Lenangio 10mg with Erythropoietic agents, cause to produced rises in risk of thrombosis. Discuss with the patients prior to starting this combination treatment.
Interaction of Lenangio 10mg with warfarin, will produce increased exposure of hemorrhage disorders. check the INR value & prothrombin time.

CONTRAINDICATION

When pregnancy period the drug is contraindicated The patients are contraindicated to hypersensitivity reaction and the Lenangio 10mg component.

OVER DOSAGE

Over dosage of Lenangio 10mg will cause neutropenia & thrombocytopenia as mainly common side effects. Give the patient general supportive treatment. check the blood cells counts regularly during the treatment.

MISSED DOSE

The missed dose of Lenangio 10mg should be avoided. If missed dose founded, then patients should be consulting with doctor specialized in oncologist Regulate the usual dosing schedule.

SIDE EFFECTS

Second primary malignancies Hepatotoxicity , Hypersensitivity reactions, Thyroid dysfunction, Fetal toxicity, Hematological toxicity, Tumor lysis syndrome, Tumor flare reactions, Increase of mortality rate.
Common side effects;
Diabetes mellitus, Rash, Insomnia, Depression, Deep vein thrombosis, Myocardial infraction, Renal failure, Squamous cell carcinoma, Basal cell carcinoma, Fatigue, Asthenia, Pyrexia, Pain, Diarrhea, Dyspepsia, Bone pain, Neck pain, Respiratory infections, UTI, Influenza, Sepsis, Headache, Anemia, Loss of appetite, Hypokalemia, Hyperglycemia, Hypocalcaemia, Dehydration, Gout.

WARNING

The some of the common life-threatening condition like :
Venous & arterial thromboembolism
Blood clotting effects
Embryo fetal damage
Hypersensitivity reactions
Hematological disorders
For all these conditions, some supportive measures should be used and provide safety measures.