Pomacel 2mg capsule - Pomalidomide | Myapplepharma

Pomacel 2mg is a Glenmark Pharmaceuticals product which is endorsed by FDA, containing an active anti-cancer drug called Pomalidomide.
Pomacel 2mg is available as orally bioavailable thalidomide derivative with various therapeutic activities such as;
Immuno modulatory
Anti-angiogenesis
Anti-neoplastic
Pomacel 2mg is like thalidomide & Lenalidomide with related to decreased rate of serum aminotransferase elevations during treatment. This may lead to severe liver injury.

INDICATION

The major therapeutic indication of Pomacel 2mg is involved in the treatment of multiple myeloma. This treatment is occurred by combining with dexamethasone for reducing the side effect associated with Pomacel 2mgomide.
Pomacel 2mg is majorly indicated in patients who are not reacts for prior two therapies like Lenalidomide & proteasome inhibitor.

DOSAGE & ADMINISTRATION

The prescribed dose of Pomacelin multiple myeloma is 4mg should be administered orally as once a day on day 1 to 21 of reciprocated 28-day cycles.
Pomacel 2mg should be concomitant with dexamethasone.
Pomacel 2mg Capsules should be taken with or without food.
During hematological toxicities:
Neutropenia;
ANC (absolute neutrophils count) <500/mcl: Postpone the Pomaceltherapy and provide CBC weekly
ANC more than or equal to 500/mcl: Continue the Pomacel 3mg daily.

WORK AS

Pomacel 2mg exhibits various activities like;
Anti-neoplastic activity:
Prohibits proliferation
Promote apoptosis of hematopoietic cancer cells
Co adjuvant with dexamethasone in both Lenalidomide sensitive & resistant myeloma cells to activate the tumor cell apoptosis

WARNING

There are two major worsening condition may occur during the treatment using with Pomacel 2mg.

Embryo fetal damage :

Pomacel 2mg Capsules are contraindicated to pregnancy period.
During the treatment, patients avoid to becoming pregnant.
Use effective contraceptives for preventing pregnancy during therapy.

DRUG INTERACTION

Pomalidomide metabolism is mediated by CYP1A2 & CYP3A4.
The concomitant use of Pomacel 2mg with CYP1A2 drugs like Fluvoxamine causes elevation of Cmax& AUC of Pomalidomide and concludes as increased concentration of Pomacelleads to higher extent of adverse effects associated with Pomalid
In this condition, reduce the dose of Pomacel 2mg and recommended.

SIDE EFFECTS

More common effects of Pomacel 2mg :
If taken during pregnancy, Severe life-threatening human birth defects
Fatigue
Weakness
Low white blood cell count
Anemia
Constipation
Nausea
Diarrhea
Shortness of breath
Upper respiratory infections
Back pain
Fever.